%0 Journal Article
%T A chiral 1,3,2-dioxaborolane derived from a natural diterpene for asymmetric reduction of prochiral ketones
%A Diego A. Cifuente
%A Carlos E. Tonn
%J Organic Communications
%D 2012
%I ACG Publications
%X The application of a chiral 1,3,2-dioxaborolane, for the sulfide complex-mediated asymmetric reduction of prochiral ketones at room temperature, are described. The B-methoxy-dioxaborolane was synthesized from 2 a ,3 a -dihydroxycativic acid, a labdane-type diterpene isolated from aerial parts of Baccharis scandens DC. Very good chemical yields (85-97%) and high enantioselectivities (62-96% ee), were obtained.
%K Asymmetric reductions
%K chiral 1
%K 3
%K 2-dioxaborolane
%K 2 a
%K 3 a -dihydroxycativic acid.
%U http://www.acgpubs.org/OC/2012/Volume%205/Issue%201/10-OC-1202-247.pdf