%0 Journal Article
%T Pitfalls associated with the therapeutic reference pricing practice of asthma medication
%A Zoltan Kalo
%A Zsolt Abonyi-Toth
%A Zoltan Bartfai
%A Zoltan Voko
%J BMC Pulmonary Medicine
%D 2012
%I BioMed Central
%R 10.1186/1471-2466-12-35
%X Real-world data were derived from the Hungarian National Health Insurance Fund database. Average doses and costs were compared between the high-dose and medium-dose SYT and SED groups. Multiple linear regressions were employed to adjust the data for differences in the gender and age distribution of patients.27,779 patients with asthma were included in the analysis. Average drug use was lower than DDD in all groups, 1.38-1.95 inhalations in both SED groups, 1.28-1.97 and 1.74-2.49 inhalations in the medium and high-dose SYT groups, respectively. Although the cost of SED based on the DDD would be much lower than the cost of SYT in the medium-dose groups, no difference was found in the actual cost of the maintenance therapy. No significant differences were found between the groups in terms of total medical costs.Cost-containment initiatives by payers may influence clinical decisions. TRP for inhalation asthma drugs raises special concern, because of differences in the therapeutic profile of pharmaceuticals and the lack of proven financial benefits after exclusion of the effect of generic price erosion. Our findings indicate that the presented TRP approach of asthma medications based on the daily therapeutic costs according to the WHO DDD does not result in reduced public healthcare spending in Hungary. Further analysis is required to show whether TRP generates additional expenditures by inducing switching costs and reducing patient compliance. Potential confounding factors may limit the generalisability of our conclusions.The question of what proportion of total healthcare costs should be financed from public resources and what proportion should be spent on pharmaceuticals is under continuous debate in Hungary [1]. Before 2006, the proportion of the total drug cost financed from public resources was larger than the average for OECD countries. Furthermore, between 2000 and 2006, the increase in public pharmaceutical expenditures exceeded the annual rate of 17%. Therefor
%U http://www.biomedcentral.com/1471-2466/12/35