%0 Journal Article
%T Introduction of new tumor marker age score in clinical practice: Validity evaluation for differentiation benign from malignant adnexal masses
%A Liki£¿-La£¿evi£¿ Ivana
%A Terzi£¿ Milan
%A La£¿evi£¿ Neboj£¿a
%A Dotli£¿ Jelena
%J Acta Chirurgica Iugoslavica
%D 2012
%I Clinical Center of Serbia, Belgrade
%R 10.2298/aci1203049l
%X OBJECTIVE: The aim of the study was to examine several tumor markers and their correlation with pathohistological findings in patients with adnexal masses. METHODS: Study involved 139 patients, 84 of them with benign, 47 with malignant and 8 with borderline adnexal tumor. Levels of CA 125, CA 19-9, CEA and CA 15-3 were obtained preoperatively and assessed regarding the specific pathohistological diagnose and the patient¡¯s age. Obtaining these results led us to divide the patient¡¯s CA 125 levels with age and by doing that we have attained a new Tumor Marker Age score (TMA score). Results: Patients with malignant adnexal tumors had significantly higher levels of CEA (p<0.05), CA 125, CA 19-9 and CA 15-3 tumor markers (p<0.01), in comparison with patients with benign tumors. TMA score highly statistically correlate with the tumor type (benignant/malignant). CONCLUSIONS: With the increase of tumor marker levels and the patient¡¯s age the malignant nature of adnexal tumors is more often. Results of our study highlight the importance of the use of combined tumor markers (at least CA-125 and CA 19-9) in women with adnexal masses. Those levels along with the patient¡¯s age and new TMA score could preoperatively predict malignant nature of the tumor. [Projekat Ministarstva nauke Republike Srbije, br. 41021]
%K tumor markers
%K adnexal masses
%K borderline
%K ovary
%U http://www.doiserbia.nb.rs/img/doi/0354-950X/2012/0354-950X1203049L.pdf