%0 Journal Article
%T Effects of local phenytoin on seroma formation after mastectomy and Axillary lymph node dissection: an experimental study on mice
%A Mehmet Eser
%A F£¿rat Tutal
%A Metin Kement
%A Selcuk Goktas
%A Levent Kaptanoglu
%A Mehmet G£¿kceimam
%A Melin Ozgun Gecer
%A Huseyin Uzun
%J BMC Surgery
%D 2012
%I BioMed Central
%R 10.1186/1471-2482-12-25
%X Two groups including eight rats in each were randomized. Saline injection was applied in the first group, whereas 1% phenytoin was locally used in the second group. Ten days after the surgery, seroma formation and wound-healing processes were evaluated using histopathological and biochemical examinations.Phenytoin significantly decreased seroma formation. Fibrosis was significantly increased and angiogenesis was significantly reduced in the phenytoin group (P£¿<£¿0.05). Increased levels of macrophage and lymphocyte infiltration was detected in the control group (P£¿<£¿0.05). No difference was detected between the groups in terms of necrosis, edema, congestion, and PNL (Polymorphonuclear leucocyte) and fibroblast infiltration.Seroma formation-reducing effect of phenytoin might have occurred over its anti-inflammatory, anti-angiogenetic, and fibrosis augmenting effects.Seroma formation isone of the most common complications after breast cancer surgery. It has been reported that seroma occurs by 5-52% after modified radical mastectomy (MRM) procedure and by 7.1-14% after sentinel lymph node biopsy (SLNB) [1-5].Seroma formation usually disappears following surgery within a few weeks. But sometimes it may persist for a few months. Prolonged therapy duration and requirement for multiple aspirations may cause trouble for patients, and more importantly it can delay adjuvant therapy and may cause increasement of treatment costs.We believe flaps are lightly attached to chest wall, and additionaly perioperative dissection may harm lymphatic and capillary vessels. Large dead space, auxillary effects of muscles to venous return may be interrupted during surgery. Finally shape of the axilla and chest wall, local inflammatory mediators and all factors mentioned above are considered responsible for seroma formation [2]. Seroma formation is seen more likely in overweight patients, patients that underwent modified radical mastectomy as opposed to simple mastectomy, and in those with incr
%K Mastectomy
%K Lymph node dissection
%K Breast cancer
%U http://www.biomedcentral.com/1471-2482/12/25