%0 Journal Article
%T Multilevel omic data integration in cancer celllines: advanced annotation and emergentproperties
%A Yuanhua Liu
%A Valentina Devescovi
%A Suning Chen
%A Christine Nardini
%J BMC Systems Biology
%D 2013
%I BioMed Central
%R 10.1186/1752-0509-7-14
%X We address the latter of these two challenges by testing an integrated approach on a known cancer benchmark: the NCI-60 cell panel. Here, high-throughput screens for mRNA, miRNA and proteins are jointly analyzed using factor analysis, combined with linear discriminant analysis, to identify the molecular characteristics of cancer. Comparisons with separate (non-joint) analyses show that the proposed integrated approach can uncover deeper and more precise biological information. In particular, the integrated approach gives a more complete picture of the set of miRNAs identified and the Wnt pathway, which represents an important surrogate marker of melanoma progression. We further test the approach on a more challenging patient-dataset, for which we are able to identify clinically relevant markers.The integration of multiple layers of omics can bring more information than analysis of single layers alone. Using and expanding the proposed integrated framework to integrate omic data from other molecular levels will allow researchers to uncover further systemic information. The application of this approach to a clinically challenging dataset shows its promising potential.
%U http://www.biomedcentral.com/1752-0509/7/14/abstract