%0 Journal Article
%T Role of increasing serum tumor necrosis factor on hyperalgesia and edema variation during different stages of adjuvant- induced arthritis in male rats
%A Zeinab Akhtari
%A Jalal Zaringhalam
%A Akram Eidi
%A Ali haeri Ruhani
%J Koomesh
%D 2013
%I Semnan Univeristy of Medical Sciences
%X Introduction: Tumor necrosis factor ¦Á (TNF-¦Á) is a potent cytokine that exerts pleiotropic functions in inflammatory symptoms. With regarding to the important role of TNF¦Á in hyperalgesia and edema induction via intra-cellular signaling pathways, we aimed to investigate the role of increasing serum TNF-¦Á on hyperalgesia and edema and spinal mu opioid receptor (mOR) expression variation during different stages of Complete Freound Adjuvant- induced arthritis in male rats.Materials and Methods: Mono-arthritis was induced by CFA and then inflammatory symptoms (hyperalgesia and edema) were assessed on day 0, 3,7th, 14 and 21 following CFAinduction. In addition, anti-TNF-¦Á was daily administered for 21 days for all different experimental groups. Spinal mOR expression were detected by western blotting. Results: Our results showed that anti-TNF¦Á administration in AA group resulted in decrease of paw volume and hyperalgesia until day 14, whereas, those symptoms were increased on day 21 following CFAinduction. Our study stated that anti- TNF¦Á antibody administration causes a significant decreasing in spinal mOR protein expression on days 14 and 21 of the study.Conclusion: This study confirmed the time-dependent and bi-directional effects of serum TNF-¦Á levsel on CFA-induced hyperalgesia, which it can say, a portion of these effects might be mediated via spinal mOR expression variation.
%K Hyperalgesia
%K Edema
%K Tumor necrosis factor-alpha
%K Receptors
%K Opioid
%K Mu
%U http://koomeshjournal.ir/browse.php?a_id=1677&sid=1&slc_lang=fa