%0 Journal Article
%T Binding interactions of porphyrin derivatives with Ca2+ ATPase of sarcoplasmic reticulum (SERCA1a)
%A Abdul Hai
%A Nadeem A. Kizilbash
%A Syeda Huma H. Zaidiand
%A Jamal Alruwaili
%J Bioinformation
%D 2013
%I 
%X The use of Porphyrin derivatives as photosensitizers in Photodynamic Therapy (PDT) was investigated by means of a molecular docking study. These molecules can bind to intracellular targets such as P-type Ca2+ ATPase of sarcoplasmic reticulum (SERCA1a). CAChe software was successfully employed for conducting the docking of Tetraphenylporphinesulfonate(TPPS), 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) Chloride (FeTPPS) and 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) nitrosyl Chloride (FeNOTPPS) with Ca2+ ATPase from sarcoplasmic reticulum of rabbit. The results show that FeNOTPPS forms the most stable complex with Ca2+ ATPase.
%K Porphyrin derivatives
%K Molecular docking
%K Photodynamic therapy
%K Photosensitizers.
%U http://www.bioinformation.net/009/97320630009409.htm