%0 Journal Article
%T Retroperitoneal teratoma with somatic malignant transformation: A papillary renal cell carcinoma in a testicular germ cell tumour metastasis following platinum-based chemotherapy
%A Nina Zeh
%A Peter J Wild
%A Peter K Bode
%A Glen Kristiansen
%A Holger Moch
%A Tullio Sulser
%A Thomas Hermanns
%J BMC Urology
%D 2013
%I BioMed Central
%R 10.1186/1471-2490-13-9
%X A 33-year-old man presented with a left testicular mass and elevated tumour markers. Staging investigations revealed retroperitoneal lymphadenopathy with obstruction of the left ureter and distant metastases. Histopathology from the left radical orchiectomy showed a mixed germ cell tumour (Stage III, poor prognosis). The ureter was stented and four cycles of cisplatin, etoposide and bleomycin chemotherapy administered. After initial remission, the patient recurred four years later with a large retroperitoneal mass involving the renal vessels and the left ureter. Left retroperitoneal lymph node dissection with en-bloc resection of the left kidney was performed.Histopathology revealed a germ cell tumour metastasis consisting mainly of mature teratoma. Additionally, within the teratoma a papillary renal cell carcinoma was found. The diagnosis was supported by immunohistochemistry showing positivity for AMACR, CD10 and focal expression of RCC and CK7. There was no radiological or histo-pathological evidence of a primary renal cell cancer.To the best of our knowledge, malignant transformation into a papillary renal cell carcinoma has not been reported in a testicular germ cell tumour metastasis following platinum-based chemotherapy. This histological diagnosis might have implications for potential future therapies. In the case of disease recurrence, renal cell cancer as origin of the recurrent tumour has to be excluded because renal cell carcinoma metastases would not respond well to the classical germ cell tumour chemotherapy regimens.Teratoma is a tumour of embryonic origin and belongs to the group of non-seminomatous germ cell tumours (GCT) [1]. Primarily, it occurs most often in the testis or ovary but may also appear in other body sites such as the central nervous system, mediastinum or retroperitoneum [2]. Non-seminomatous GCT can be pure teratoma but mixed forms with other non-seminomatous histologies occur more frequently. However, teratoma is often the only comp
%K Retroperitoneal teratoma
%K Malignant transformation
%K Germ cell tumour metastasis
%K Renal cell cancer
%U http://www.biomedcentral.com/1471-2490/13/9