%0 Journal Article %T Synthesis, characterization and antimicrobial activity of some new pyrimidines containing tetrazole %A P.B. Mohite %A R.B. Pandhare %A S.G. Khanage %J Biointerface Research in Applied Chemistry %D 2012 %I Comporter SRL %X In attempt to find new pharmacologically active molecules, we report here the synthesis and the in vitro antimicrobial activity of various new pyrimidines containing 5-phenyl tetrazole. The 3-(substituted phenyl) -1-(5-phenyl-1H-tetrazol-1-yl) prop-2-en-1-one[2a-f] were prepared by the reaction of 5-phenyl 1-acetyl tetrazole with different aromatic aldehydes in the presence of an alkaline medium. Reaction of [2a-f] with urea and thiourea resulted in 4-(substituted phenyl)-6-(5-phenyl-1H-tetrazol-1-yl)pyrimidin-2-ol [3a-f] and 4-(substituted phenyl)-6-(5-phenyl-1H-tetrazol-1-yl)pyrimidine-2-thiol [4a-f] respectively. The synthesized compounds were identified by spectral data and evaluated for their in vitro antibacterial and antifungal properties. %K Pyrimidine %K Tetrazole %K Anti-microbial Activit %U http://biointerfaceresearch.com/wp-content/uploads/downloads/2012/05/33.BRIAC_.Mohite.pdf