%0 Journal Article
%T TGFB1 codon 10 polymorphism and its association with the development of myopia: a case-control study
%A A. Sandhya
%J Biology and Medicine
%D 2011
%I 
%X Excessive axial elongation in progressive high myopia is associated with scleral remodeling events resulting indiminished sclera-fibril architecture of the eye. Transforming Growth Factor beta (TGF-¦Â) is an importantpleotropic growth factor that modulates the levels of specific extracellular matrix (ECM) proteins during scleralremodeling. In the present case-control association study (207 high myopia, 96 low myopia and 250 controlcases), we aimed to investigate the genetic association of TGFB1 codon 10 polymorphism at exon1 (T869C) inmyopia patients from South Indian population using PCR-RFLP technique. Genotype distribution in high myopiapatients did not reveal significant variation, but there was a slight elevation of heterozygote TC frequency (21.2%)compared to control group (16.8%). However, low myopia cases showed elevated CC genotype frequency(14.6%) as compared to controls (8.0%). Elevated CC genotype frequency was observed in low myopia groupamong males (21.4% vs 9.3%), and cases with early onset (23.1%), familial incidence (17.2%) and with noparental consanguinity (15.5%). Our results suggested that Individuals with CC genotype might carry sex specificrisk to myopia progression especially in early onset myopia cases.
%K Axial elongation
%K scleral remodeling
%K high myopia
%K transforming growth factor beta
%K polymorphism
%U http://biolmedonline.com/Articles/Vol3_4_2011/Vol3_4_18-24.pdf