%0 Journal Article
%T GABBR1 has a HERV-W LTR in its regulatory region ¨C a possible implication for schizophrenia
%A Hegyi Hedi
%J Biology Direct
%D 2013
%I BioMed Central
%R 10.1186/1745-6150-8-5
%X Schizophrenia is a complex disease with uncertain aetiology. We suggest GABBR1, GABA receptor B1 implicated in schizophrenia based on a HERV-W LTR in the regulatory region of GABBR1. Our hypothesis is supported by: (i) GABBR1 is in the 6p22 genomic region most often implicated in schizophrenia; (ii) microarray studies found that only presynaptic pathway-related genes, including GABA receptors, have altered expression in schizophrenic patients and (iii) it explains how HERV-W elements, expressed in schizophrenia, play a role in the disease: by altering the expression of GABBR1 via a long terminal repeat that is also a regulatory element to GABBR1. Reviewers This paper was reviewed by Sandor Pongor and Martijn Huynen.
%K Schizophrenia
%K Human endogenous retrovirus
%K HERV-W
%K long terminal repeat
%K LTR
%K GABA
%K GABBR1
%K GABA receptor
%K Enhancer
%K Silencer
%U http://www.biology-direct.com/content/8/1/5