%0 Journal Article %T Bioinformatics clouds for big data manipulation %A Dai Lin %A Gao Xin %A Guo Yan %A Xiao Jingfa %J Biology Direct %D 2012 %I BioMed Central %R 10.1186/1745-6150-7-43 %X As advances in life sciences and information technology bring profound influences on bioinformatics due to its interdisciplinary nature, bioinformatics is experiencing a new leap-forward from in-house computing infrastructure into utility-supplied cloud computing delivered over the Internet, in order to handle the vast quantities of biological data generated by high-throughput experimental technologies. Albeit relatively new, cloud computing promises to address big data storage and analysis issues in the bioinformatics field. Here we review extant cloud-based services in bioinformatics, classify them into Data as a Service (DaaS), Software as a Service (SaaS), Platform as a Service (PaaS), and Infrastructure as a Service (IaaS), and present our perspectives on the adoption of cloud computing in bioinformatics. Reviewers This article was reviewed by Frank Eisenhaber, Igor Zhulin, and Sandor Pongor. %K Cloud computing %K Bioinformatics %K Big data %K Data storage %K Data analysis %U http://www.biology-direct.com/content/7/1/43