%0 Journal Article
%T Ameliorative effect of Vitamin E on the deleterious effect of Amodiaquine hydrochloride (AQ.HCl) on the reproductive function of the adult cyclic Sprague-Dawley (S-D) rats
%A SC Gbotolorun
%J Biology and Medicine
%D 2012
%I 
%X This study determined whether exogenous supplementation with Vitamin E could confer ameliorative effect againstthe deleterious effect of AQ.HCl on ovarian function of matured S-D rats. Thirty S-D rats divided into two groups wereused in this study: Group A ¨C determined the effect of AQ.HCl 1 Vitamin E administered for 28 days on the oestrouscycle and antioxidant activities of superoxide dismutase (SOD) and catalase (CAT). Group B ¨C determined the effectof a single dose of AQ.HCl 1 Vitamin E administered at 5 p.m. on proestrus on ovulation and serum concentrationsof follicle stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL). The exogenous supplementationwith Vitamin E increased (p ªÍ 0.05) the length of the oestrous cycle and the diestrus phase, decreased the activitiesof CAT and SOD slightly, and did not hinder ovulation in adult S-D rats. Vitamin E proffered ameliorative effect againstthe deleterious effect of AQ.HCl through its antioxidant activity.
%K Vitamin E
%K oestrous cycle
%K catalase
%K superoxide dismutase
%K AQ.HCl
%U http://www.biolmedonline.com/Articles/Vol4_3_2012/Vol4_3_141-146_BM-1.pdf