%0 Journal Article
%T Homeopathic potencies of Opium in alcohol dependence: exploratory open-label study
%A Ubiratan Cardinalli Adler
%A Ana Elisa Madureira Padula
%A Amarilys de Toledo Cesar
%A Maristela Schiabel Adler
%J International Journal of High Dilution Research
%D 2012
%I Universidade Estadual Paulista
%X Background: The conventional pharmacological options for the treatment of alcoholism are limited, which led to the search for solutions in alternative or complementary medicine (CAM). Homeopathy is a CAM modality recognized as medical specialty in Brazil. According to the clinical experience of the early homeopaths, Opium was used to treat patients with alcohol dependence. Aim: to perform a preliminary assessment of the effectiveness and tolerability of fifty-millesimal potencies of Opium in the treatment of alcohol-dependent patients. Methods: exploratory, prospective, open-label trial, with pre-treatment measures as control. Confidence intervals were used to estimate the magnitude of the clinical differences. Results: a total of 14 patients were included, from which 12 were evaluated (intention to treat analysis - ITT). There was a significant reduction in the average daily alcohol consumption (-29.37 units of alcohol/day; 95% CI=10.63; 48.11) and in the severity of alcohol dependence, measured by the mean score of the Short Alcohol Dependence Data questionnaire (-10.17; 95% CI= 4.12; 16.22). No serious adverse events were reported. Randomized controlled studies with larger samples are needed.
%K alcohol dependence
%K homeopathy
%U http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/view/548