%0 Journal Article
%T Antiepidermal Growth Factor Receptor Monoclonal Antibodies: Applications in Colorectal Cancer
%A Efat Azizi
%A Adam Kittai
%A Peter Kozuch
%J Chemotherapy Research and Practice
%D 2012
%I Hindawi Publishing Corporation
%R 10.1155/2012/198197
%X Patients with metastatic colorectal cancer have a poor prognosis and present a challenge to clinicians. The role of the antiepidermal growth factor receptor (EGFR) pathway in tumorogenesis and tumor progression has been well defined. This paper will review the use of anti-EGFR monoclonal antibodies in the treatment of operable, as well as metastatic colorectal cancer both in the setting of KRAS mutation unselected patients and later in KRAS wild-type patients. Active investigations designed to further identify predictive biomarkers that may be potentially druggable are reviewed as well.
%U http://www.hindawi.com/journals/chrp/2012/198197/