%0 Journal Article
%T Preparation and In Vivo Evaluation of Dichloro(1,2-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles
%A Hardeep S. Oberoi
%A Natalia V. Nukolova
%A Yi Zhao
%A Samuel M. Cohen
%A Alexander V. Kabanov
%A Tatiana K. Bronich
%J Chemotherapy Research and Practice
%D 2012
%I Hindawi Publishing Corporation
%R 10.1155/2012/905796
%X The therapeutic performance of oxaliplatin can be improved by incorporating the central cis-dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt) motif into the core cross-linked block copolymer micelles. We describe here the preparation, cellular uptake, and in vivo evaluation of core cross-linked micelles loaded with DACHPt. Stable drug-loaded micelles were prepared at high drug loading (~25 w/w%) and displayed a considerably increased in vitro cytotoxicity compared to free oxaliplatin against A2780 ovarian cancer cells. The DACHPt-loaded micelle formulation was well tolerated in mice and exhibited improved antitumor activity than oxaliplatin alone in an ovarian tumor xenograft model.
%U http://www.hindawi.com/journals/chrp/2012/905796/