%0 Journal Article
%T Reduction of glucose intolerance with high fat feeding is associated with anti-inflammatory effects of thioredoxin 1 overexpression in mice
%A Adam B. Salmon
%A Lisa C. Flores
%A Yan Li
%A Holly Van Remmen
%J Pathobiology of Aging & Age-related Diseases
%D 2012
%I 
%R 10.3402/pba.v2i0.17101
%X Aging is associated with reduced ability to maintain normal glucose homeostasis. It has been suggested that an age-associated increase in chronic pro-inflammatory state could drive this reduction in glucoregulatory function. Thioredoxins (Trx) are oxido-reductase enzymes that play an important role in the regulation of oxidative stress and inflammation. In this study, we tested whether overexpression of Trx1 in mice [Tg(TRX1)+/0] could protect from glucose metabolism dysfunction caused by high fat diet feeding. Body weight and fat mass gains with high fat feeding were similar in Tg(TRX1)+/0 and wild-type mice; however, high fat diet induced glucose intolerance was reduced in Tg(TRX1)+/0 mice relative to wild-type mice. In addition, expression of the pro-inflammatory cytokine TNF-¦Á was reduced in adipose tissue of Tg(TRX1)+/0 mice compared to wild-type mice. These findings suggest that activation of thioredoxins may be a potential therapeutic target for maintenance of glucose metabolism with obesity or aging.
%K oxidative stress
%K diabetes
%K obesity
%K glucose homeostasis
%K aging
%U http://www.pathobiologyofaging.net/index.php/pba/article/view/17101/pdf_1