%0 Journal Article
%T Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance
%A Dea Shahinas
%A Asongna Folefoc
%A Dylan R. Pillai
%J Pathogens
%D 2013
%I MDPI AG
%R 10.3390/pathogens2010033
%X Malaria continues to exact a great human toll in tropical settings. Antimalarial resistance is rife and the parasite inexorably develops mechanisms to outwit our best drugs, including the now first-line choice, artesunate. Novel strategies to circumvent resistance are needed. Here we detail drug development focusing on heat shock protein 90 and its central role as a chaperone. A growing body of evidence supports the role for Hsp90 inhibitors as adjunctive drugs able to restore susceptibility to traditionally efficacious compounds like chloroquine.
%K malaria
%K hsp90
%K antimalarial resistance
%U http://www.mdpi.com/2076-0817/2/1/33