%0 Journal Article
%T Gross and histopathological findings in Cercopithecus aethiops with experimental Cyclospora infection in Kenya
%A Nguhiu PN
%A Wamae CN
%A Magambo JK
%A Mbuthia PG
%J Pathology and Laboratory Medicine International
%D 2012
%I Dove Medical Press
%X Purity N Nguhiu1, Claire N Wamae2,3, Japheth K Magambo4, Paul G Mbuthia5, Daniel C Chai6, Dorcas S Yole61Department of Veterinary Services, Kabete, Ministry of Livestock Development, Nairobi, 2Directorate of Research and Development, Kenya Methodist University, Meru, 3Kenya Medical Research Institute, Nairobi, 4Meru University College of Science and Technology, Meru, 5Department of Veterinary Pathology, Microbiology and Parasitology, University of Nairobi, 6Department of Tropical Infectious Diseases, Institute of Primate Research, Karen, Nairobi, KenyaAbstract: In 2009, experimental Cyclospora infections were established in two juvenile female and two adult male Cercopithecus aethiops (African green monkeys) at Nairobi's Institute of Primate Research (IPR). The study animals were humanely sacrificed, and gross and histopathological evaluation was done at seven weeks post-infection. On gross examination, the juveniles had no abnormalities except for a slight enlargement of the mesenteric lymph nodes, while the adults displayed more pathology of enlarged lymph nodes, hemorrhagic gastrointestinal tracts, widespread necrotic foci of the liver, and enlarged spleens. Significant histopathological findings were observed in both the juveniles and adults, which ranged from mild inflammatory reactions in the stomach and intestines to intense cellular infiltrations with mitotic activity and lymphocytic infiltrations around the periportal area of the livers. The lymph nodes had extensive hyperplasia with many mitotic cells.Keywords: Cyclospora spp., cyclosporiasis, nonhuman primates, pathological findings, histopathological findings, African green monkeys
%U http://www.dovepress.com/gross-and-histopathological-findings-in-cercopithecus-aethiops-with-ex-a9885