%0 Journal Article
%T Marcadores serol車gicos y moleculares de infecci車n por el virus de la hepatitis B en estudiantes universitarios colombianos Serological and molecular markers for Hepatitis B virus in university students
%A Henry Bautista Amorocho
%A Yeny Zulay Castellanos Dom赤nguez
%A Ana Elvira Farf芍n Garc赤a
%J Revista Colombiana de Gastroenterologia
%D 2012
%I Asociaci車n Colombiana de Gastroenterolog赤a
%X Introducci車n: Reportes de la OMS demuestran que la carga de infecci車n por el virus de la hepatitis B (VHB) var赤a de acuerdo con la regi車n geogr芍fica y el grupo de riesgo. Prop車sito: Determinar la prevalencia de infecci車n por el VHB y el estatus de vacunaci車n en estudiantes universitarios de Bucaramanga. Metodolog赤a: Estudio descriptivo de corte transversal realizado en el 2010. Se incluyeron 1.298 estudiantes de cinco universidades. Se identificaron marcadores serol車gicos de infecci車n para el VHB por ELISA y el genoma viral se detect車 mediante PCR anidado. Resultados: Se estableci車 infecci車n activa en 0,15%, confirmada por PCR; infecci車n resuelta a 0,60%; 1,1% anti-HBc aislado, 30,2% vacunados y 67,9% susceptibles. No se evidenci車 hepatitis B oculta. Conclusiones: La baja prevalencia de infecci車n por el virus de la hepatitis B reportada en el presente estudio contrasta con el patr車n epidemiol車gico intermedio descrito en la regi車n. Se encontr車 una baja cobertura de vacunaci車n y ausencia de hepatitis B oculta en los estudiantes universitarios. Introduction: Reports from the World Health Organization (WHO) show that the prevalence of hepatitis B virus (HBV) infections varies by geographical region and risk group. Purpose: The purpose of this study was to determine the prevalence of HBV infections, as well as the vaccination status, among university students from Bucaramanga. Methodology: This was a cross sectional study conducted in 2010 which included 1298 students from five universities. Serological markers for HBV infection were detected using ELISA. Viral genomes were detected with nested polymerase chain reaction (PCR). Results: Active infections were established in 0.15% of the study population, and this finding was confirmed by PCR. Resolved infections were identified in 0.60% of the population. Isolated anti-HBc antibodies were found, 30.2% of vaccinated individuals. 67.9% of the study population was susceptible. No occult HBV was detected. Conclusions: The low prevalence of HBV infections reported in this study contrasts with the intermediate epidemiological pattern described in the region. We found poor vaccination coverage and absence of occult hepatitis B among these university students.
%K Virus de la hepatitis B
%K prevalencia
%K serolog赤a
%K PCR anidado
%K Colombia
%K estudiantes
%K Hepatitis B virus
%K prevalence
%K serology
%K nested PCR
%K Colombia
%K students
%U http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-99572012000400005