%0 Journal Article
%T Beneficial effect of low dose Amlodipine vs Nifedipine on serum cholesterol profile of rabbits receiving standard diet.
%A Bavane DS
%A Rajesh CS
%A Gurudatta Moharir
%A Bharatha Ambadasu
%J International Journal of Medical Research and Health Sciences
%D 2013
%I Sumathi Publications
%X To investigate the effect of low dose amlodipine v/s nifedipine on serum cholesterol profile of rabbits receiving standard diet. Methods: Fourty Newzealand rabbits were selected for the study. Their cholesterol profile was estimated at the beginning of the study. Rabbits were grouped into 4 groups receiving standard diet (control group), standard diet + vehicle propylene glycol, standard diet + nifedipine dissolved in propylene glycol and standard diet + amlodipine dissolved in propylene glycol. Along with standard diet they were treated with respective drugs for ten weeks. At the end of ten weeks serum cholesterol profile was estimated. Results: The cholesterol profile was estimated at the beginning and at the end of ten weeks. Total cholesterol in the amlodipine group decreased from 97¡À4.06 mg/dl to 90¡À4.2 mg/dl and HDL-Cholesterol increased from 32.01¡À4.40 mg/dl to 37¡À4.60 mg/dl after 10 week treatment but these changes were not significant. LDL cholesterol decreased significantly in rabbits with low dose of amlodipine from 55.42¡À3.32 mg/dl to 32.40¡À3.22 mg/dl and. In the nifedipine group there was a slight increase in total cholesterol from 102.49¡À5.16 mg/dl to 106¡À5.39 mg/dl, HDL cholesterol from 34.10¡À2.80 to 35.16¡À2.82 mg/dl and LDL cholesterol also increased from 56.20¡À2.20 mg/dl to 59.00¡À2.20 mg/dl after 10 week treatment. Conclusion: The study shows amlodipine produces favorable alterations in serum cholesterol profile
%K : Cholesterol profile
%K Standard diet
%K Amlodipine
%K Nifedipine
%U http://ijmrhs.com/wp-content/uploads/2013/01/Bavane-et-al.pdf