%0 Journal Article
%T Immunohistochemical evaluation of transforming growth factor (TGF-b1) in malignant salivary gland tumours
%A Dionisios Fotopoulos
%A Nikolaos Papadogeorgakis
%A Ioannis Iatrou
%A Sofia Tseleni
%A Alexandra Sklavounou
%A Constantinos Alexandridis
%J Hellenic Archives of Oral and Maxillofacial Surgery
%D 2011
%I Hellenic Association for Oral and Maxillofacial Surgery
%X The development of malignant tumours is defined by interactions between tumour cells and the stroma through cell membrane proteins and the release of cytokines. ¦©t has been indicated that high concentrations of transforming growth factor (TGF-b1) inaggressive tumours of the breast, prostate etc. can promotecarcinogenesis. Aim: The aim of this study is to examine TGF-b1expression in malignant salivary gland tumours and correlateit with clinical parameters. Material and methods: 54 specimens of malignant salivary gland tumours obtained between 1996 and 2008(12 years) were the material of the study. 54 cases were evaluated 29 male and 25 female, 16-75 years of age. Results: TGF-b1 expression was weak and focal, locatedin neoplastic cells, as well as in the stroma. A positive correlation to tumour staging was also detected. Conclusions: TGF-b1 expression in malignant salivary gland tumours and its positive correlation with tumour staging provide a useful basis for the further investigation of its potential role as a prognostic index.
%K Transforming Growth Factor (TGF-b1)
%K epithelial-mesenchymal transitions
%K malignant salivary
%K gland tumours
%U http://www.haoms.org/haomsjournal/2011teuxos_1_article_1.pdf