%0 Journal Article
%T The prognostic value of estimated glomerular filtration rate, amino-terminal portion of the pro-hormone B-type natriuretic peptide and parameters of cardiopulmonary exercise testing in patients with chronic heart failure
%A Hein Verberne
%A Aukje van der Spank
%A Paul Bresser
%A G.Aernout Somsen
%J Heart International
%D 2012
%I Wichtig Editore, Milan
%R 10.4081/hi.2012.e13
%X The aim of this study was to evaluate the prognostic value of renal function in relation to amino-terminal portion of the pro-hormone B-type natriuretic peptide (NT-proBNP) and parameters of cardiopulmonary exercise testing in predicting mortality and morbidity in patients with moderate chronic heart failure (CHF). Sixty-one CHF patients were included in the study. Patients¡¯ characteristics were: age 64.3¡À11.6 years; New York Heart Association class I/II/III: 14/37/10; left ventricular ejection fraction: 0.30¡À0.13 (%); NT-proBNP: 252.2¡À348.0 (ng/L); estimated creatinine clearance (e-CC): 73.6¡À31.4 (mL/min); estimated glomerular filtration rate (e-GFR): 66.1¡À24.6 (mL/min/1.73 m2); the highest O2 uptake during exercise (VO2-peak): 1.24¡À0.12 mL/kg/min; VO2/workload: 8.52¡À1.81 (mL/min/W)]. During follow up (59.5¡À4.0 months) there were 15 cardiac deaths and 16 patients were hospitalized due to progression of heart failure. NT-proBNP and VO2/workload were independently associated with cardiac death (P=0.007 and P=0.006, respectively). Hospitalization for progressive CHF was only associated with NT-proBNP (P=0.002). The combined cardiac events (cardiac death and hospitalization) were associated with NT-proBNP and VO2/workload (P=0.007 and P=0.005, respectively). The addition of estimates of renal function (neither serum creatinine nor e-GFR) did not improve the prognostic value for any of the models. In conclusion, in patients with moderate CHF, increased NT-proBNP and reduced VO2/workload identify those with increased mortality and morbidity, irrespective of estimates of renal function.
%K VO2
%K workload
%K NT-proBNP
%K prognosis
%K chronic heart failure
%K renal function
%U http://www.pagepress.org/journals/index.php/hi/article/view/3851