%0 Journal Article
%T Lipase-catalysed sequential kinetic resolution of ¦Á-lipoic acid
%A Zhao Wang
%J Maejo International Journal of Science and Technology
%D 2012
%I Maejo University
%X Lipase from Aspergillus sp. WZ002 was employed to kinetically resolve racemic¦Á-lipoic acid by a sequential esterification process. Though the remoteness of this substrate¡¯sstereocentre from the reaction centre provided a significant challenge, the introduction ofsequential kinetic resolution dramatically enhanced the lipase¡¯s enantioselectivity foresterification at the terminal carbonyl group, producing the desired (R)-enantiomer virtuallyenantiomerically pure. The enantiomeric excess of the (R)-enantiomer increased from 52% inthe first step to 92% for in second step.
%K esterification
%K lipase-catalysed reactions
%K ¦Á-lipoic acid
%K sequential kinetic resolution
%U http://www.mijst.mju.ac.th/vol6/152-158.pdf