%0 Journal Article
%T Molecular Aspects of Hepatocellular Carcinoma Caused by Hepatitis C Virus
%A Ali Karami
%A Seyed-Moayed Alavian
%A Ali Najafi
%A Mohammad Javad Hosseini
%J Hepatitis Monthly
%D 2006
%I Kowsar Corporation
%X The hepatitis C virus (HCV) is a small, enveloped, single-stranded positive sense RNA virus with a diameter of about 50 nm belonging to the Hepacivirus genus of the family Flaviviridae. The HCV genome is translated to produce a single protein of around 3011 amino acids. This "polyprotein" is then proteolytically processed by viral and cellular proteases to produce structural (core protein, envelope glycoproteins E1 and E2, ARFP/F protein, p7) and nonstructural (NS2-3 autoprotease, NS3-4A, NS4B, NS5A, NS5B) proteins. Hepatocellular carcinoma (HCC) is one of the most frequent malignant tumors worldwide, with increasing incidence. It is estimated that approximately 300-400 thousands of people in the IRAN and 4 million in the United States are persistently infected. It is important for tumor control to identify the factors that predispose patients to death. A large number of molecular factors have been shown to associate with the invasiveness of HCC, and have potential prognostic significance.
%K Hepatitis C Virus (HCV)
%K Hepatocellular Carcinoma
%K Genomic and Proteomics
%U http://www.hepmon.com/pdf/Molecular_Aspects_of_Hepatocellular_Carc.pdf