%0 Journal Article
%T Differing effect of systemic anti psoriasis therapies on platelet physiology - a case report and review of literature
%A Batya B Davidovici
%A Mary M Sullivan-Whalen
%A Patricia Gilleaudeau
%A James G Krueger
%J BMC Dermatology
%D 2010
%I BioMed Central
%R 10.1186/1471-5945-10-2
%X This is a case report and review of the literature. We present a patient with long standing severe psoriasis vulgaris with marked thrombocytosis. His thrombocytosis did not correlate with disease severity but rather with the different treatments that he was exposed to, subsiding only during treatment with anti Tumor Necrosis Factor (TNF)- agents. A literature review revealed that in rheumatoid arthritis, another systemic inflammatory disease; interleukin (IL)-6 might be implicated in causing thrombocytosis.This unique case report illustrates that different systemic treatments for psoriasis might have implications beyond the care of skin lesions. This insight is especially important in psoriasis patients in view of their deranged hemostatic balance toward a prothrombotic state, which might increase the risk of thrombosis and CVD. Therefore, further studies analyzing the effect of different drugs on platelets physiology are warranted.Psoriasis is a chronic relapsing prevalent disease affecting 2-4% of the world's population [1-3]. Severe psoriasis is a disabling disease affecting the physical and emotional well-being of patients, and its effect on quality of life is similar to that seen with other major medical diseases such as diabetes, rheumatoid arthritis, and cancer [4,5].Moreover, it is increasingly being recognized that in patients with severe or long-lasting disease, psoriasis is not merely a skin disease but is probably associated with other co-morbidities. Recently, studies based on large cohorts showed that severe psoriasis was association with metabolic derangements [6] and increased mortality [7]. Cardio-vascular diseases (CVD) were found to be the most common cause of death [8,9]. These data emphasize that the increased risk for occlusive vascular events in patients with severe psoriasis can be attributed not only to metabolic dysregulation, traditional lifestyle risk factors such as obesity, smoking or alcohol which have been also reported in these patie
%U http://www.biomedcentral.com/1471-5945/10/2