%0 Journal Article
%T THE EFFECTS OF DIETARY FOOD FORTIFIED WITH VITAMIN B4 ON LIPID PROFILES IN SERUM AND LIVER TISSUE
%A Yohanes Buang
%J Makara Seri Kesehatan
%D 2010
%I Universitas Indonesia
%X The effects of dietary food fortified with vitamin B4 on lipid profiles in serum and liver tissue were studied. Rats were paired-fed a 0.25% vitamin B4 diet or a diet without vitamin B4 for 10 days. Serum lipid levels were measured using enzyme assay kits. Lipids of liver tissues were extracted and the lipid contents were determined. A piece of liver was prepared to determine the activities of fatty acid synthase (FAS) and fatty acid ¦Â-oxidation. The results showed that animals fed a food fortified with vitamin B4 had higher level of serum TG, PL, total cholesterol, and high density lipoprotein. Their increases were approximately by 74%, 20%, 27%, and 27%, respectively. The significant changes in liver lipid were only found in PL component. This treatment promoted FAS activity, but impaired the fatty acid ¦Â-oxidation. In conclusion: Dietary food fortified with vitamin B4 induces hypertriglyceridemia and liver PL level.
%K Keywords: cholesterol
%K high density lipoprotein
%K serum lipid
%K triglyceride
%K vitamin B4
%U http://journal.ui.ac.id/health/article/view/639