%0 Journal Article
%T A Synchronous undifferentiated nasopharyngeal carcinoma and infiltrating ductal carcinoma of the breast successfully treated with induction chemotherapy followed by local control of both tumours: a case report
%A Mohamed Mesmoudi
%A Tarik Mahfoud
%A Nabil Ismaili
%A Khadija Rami
%A Meryem Kamouni
%A Laila Jroundi
%A Hassan Errihani
%J BMC Ear, Nose and Throat Disorders
%D 2011
%I BioMed Central
%R 10.1186/1472-6815-11-6
%X We report here an exceptional case of a 47 years old Moroccan woman presenting two synchronous cancers, the first in the nasopharynx and the second in the breast. The patient was treated successfully with a combined strategy associating chemotherapy, radiation therapy, and surgery. She remains disease free after 27 months of follow up.Treatment strategy in the case of multiple primary cancers remains controversial because of the variety of presentations; initial aggressive treatment reports good results.The incidence of multiple primary cancers (MPC) is estimated between 0,73% and 11,7% [1]. The association of different cancers is classified in two categories depending on the timing of their discovery; synchronous in which the cancers occur at the same time or within two months, as the case that we report, or metachronous in which the cancers follow in sequence of more than two months apart [2].The undifferentiated carcinoma of the nasopharynx is a common cancer in North Africa and in the Mediterranean basin, but the incidence of a double malignancy including a nasopharyngeal carcinoma is very uncommon. We report here a case of an undifferentiated nasopharyngeal carcinoma with a synchronous breast cancer treated successfully with induction chemotherapy followed by local control of both tumours.A 47 years old Moroccan woman with a familial history of a father dead from a colorectal cancer, and a maternal aunt dead from a breast cancer, presented to our institute with complaints of nasal obstruction, headache, and ear fullness for three months, and skin changes on the right breast for two months. She did not breastfeed her four children, had a regular menstrual cycle, and took oral contraception.On physical examination, the right breast had a 6 กม 5 cm lump on retroareolar area fixed to the skin with thickening of the whole breast and nipple retraction. The axillae and the cervical regions were free of any adenopathy. Mammogram showed an increase in density on the righ
%U http://www.biomedcentral.com/1472-6815/11/6