%0 Journal Article
%T Self-Assembly and Hydrogelation of Peptide Amphiphiles
%A Irwansyah
%A Riwandi Sihombing
%A Wahyudi Priyono Suwarso
%J Makara Seri Sains
%D 2012
%I Universitas Indonesia
%X Seven peptide amphiphiles were successfully synthesized using solid phase peptide synthesis method. Peptide amphiphiles were characterized using matrix assisted laser desorption/ionization (MALDI). Atomic force microscopy (AFM) study showed that peptide amphiphiles having glycine, valine, or proline as linker, self-assembled into 100-200 nm nanofibers structure. According to our research, both peptide amphiphile with positive and negative charges bear similar self-assembly properties. Peptide amphiphile also showed its capability as low molecular weight gelator (LMWG). Peptide amphiphiles bearing C-16 and C-12 as alkyl showed better hydrogelation properties than C-8 alkyl. Five out of seven peptide amphiphiles have minimum gelation concentration (MGC) lower than 1% (w/v).
%K low molecular weight gelator
%K MALDI
%K peptide amphiphile
%K self-assembly
%K solid phase peptide synthesis
%U http://journal.ui.ac.id/index.php/science/article/view/1281/1178