%0 Journal Article
%T Association of the 4£¿g/5£¿g polymorphism of plasminogen activator inhibitor-1 gene with sudden sensorineural hearing loss. A case control study
%A Seong H Cho
%A Haimei Chen
%A Il S Kim
%A Chio Yokose
%A Joseph Kang
%A David Cho
%A Chun Cai
%A Silvia Palma
%A Micol Busi
%A Alessandro Martini
%A Tae J Yoo
%J BMC Ear, Nose and Throat Disorders
%D 2012
%I BioMed Central
%R 10.1186/1472-6815-12-5
%X The association of the 4£¿G/5£¿G PAI-1 polymorphism with the development and clinical outcome of SSNHL is evaluated via a case control study. 103 patients with SSNHL and 113 age and sex-matched controls were enrolled at University of Ferrara, Italy and hearing loss outcome was measured at least 3£¿months after the onset of hearing loss. DNA was isolated from peripheral blood using the QIAamp kit and the 4£¿G/5£¿G polymorphism in the £¿675 promoter region was genotyped with an allele-specific PCR. Genotype distribution was tested in patients and compared to controls by chi-square and odd-ratio analysis. The codominant and recessive models were used for the multiple logistic regression analyses of the PAI-1 gene allele.In this population, 5£¿G/5£¿G genotype had a two-time lower frequency in SSNHL patients compared to healthy controls (15.5% vs 30.1%) and was associated with decreased odds compared to 4£¿G/5£¿G genotype (OR 0.37, 95% CI 0.19-0.75, p£¿=£¿0.005). In addition, the patients with 5£¿G/5£¿G genotype showed a trend of more than 2 times higher ratio of hearing recovery (> 20£¿dB) after systemic corticosteroid treatment compared to 4£¿G/5£¿G genotype (OR 2.3, 95% CI 0.32 - 16.83, p£¿=£¿0.39), suggesting a better clinical outcome.The 5£¿G/5£¿G genotype of PAI-1 may be associated with a reduced risk of SSNHL in the Italian population.
%K Sudden hearing loss
%K Plasminogen activator inhibitor-1
%K 4£¿G/5£¿G polymorphism
%U http://www.biomedcentral.com/1472-6815/12/5/abstract