%0 Journal Article
%T Serum levels of pancreatic stone protein (PSP)/reg1A as an indicator of beta-cell apoptosis suggest an increased apoptosis rate in hepatocyte nuclear factor 1 alpha (HNF1A-MODY) carriers from the third decade of life onward
%A Siobhan Bacon
%A Ma Peyh Kyithar
%A Jasmin Schmid
%A Syed R Rizvi
%A Caroline Bonner
%A Rolf Graf
%A Jochen HM Prehn
%A Maria M Byrne
%J BMC Endocrine Disorders
%D 2012
%I BioMed Central
%R 10.1186/1472-6823-12-13
%X We analysed serum PSP/reg1A levels and correlated with clinical and biochemical parameters in subjects with HNF1A-MODY, glucokinase (GCK-MODY), and type 1 diabetes mellitus. A control group of normoglycaemic subjects was also analysed.PSP/reg1A serum levels were significantly elevated in HNF1A-MODY (n£¿=£¿37) subjects compared to controls (n£¿=£¿60) (median£¿=£¿12.50£¿ng/ml, IQR£¿=£¿10.61-17.87£¿ng/ml versus median£¿=£¿10.72£¿ng/ml, IQR£¿=£¿8.94-12.54£¿ng/ml, p£¿=£¿0.0008). PSP/reg1A correlated negatively with insulin levels during OGTT, (rho£¿=£¿£¿0.40, p£¿=£¿0.02). Interestingly we noted a significant positive correlation of PSP/reg1A with age of the HNF1A-MODY carriers (rho£¿=£¿0.40 p£¿=£¿0.02) with an age of 25£¿years separating carriers with low and high PSP/reg1A levels. Patients with type 1 diabetes mellitus also had elevated serum levels of PSP/reg1A compared to controls, however this was independent of the duration of diabetes.Our data suggest that beta cell apoptosis contributes increasingly to the pathophysiology of HNF1A-MODY in patients 25£¿years and over. PSP/reg1A may be developed as a serum marker to detect increased beta-cell apoptosis, or its therapeutic response.
%K Maturity onset diabetes of the young (MODY)
%K Apoptosis
%K Serum biomarker
%K Beta-Cell
%K Type 1 diabetes
%K Pancreatic stone protein (PSP)
%K Regenerating gene 1A (reg1A)
%U http://www.biomedcentral.com/1472-6823/12/13/abstract