%0 Journal Article
%T Biological screening of araripe basin medicinal plants using Artemia salina Leach and pathogenic bacteria
%A da Costa Jos¨¦ Galberto
%A Campos Adriana
%A Brito Samara
%A Pereira Carla Karine
%J Pharmacognosy Magazine
%D 2010
%I Medknow Publications
%X Background: Many medicinal plant species from the Araripe Basin are widely known and used in folk medicine and for commercial manufacturing of phytotherapeutic products. Few ethnobotanical and pharmacological studies have been undertaken in this region, however, in spite of the great cultural and biological diversity found there. Materials and Methods : Extracts of 11 plant species collected from Cear¦Á state, Brazil, were subjected to the brine shrimp lethality test in order to detect potential sources of novel cytotoxic, antitumor compounds. The larvicidal activity, based on the percentage of larval mortality, was evaluated after 24 h exposure to the treatments. Results: All species tested showed good larvicidal activity as compared to a reference compound and literature data. The extract from Vanillosmopsis arborea was the most active with an LC 50 of 3.9 ¦Ìg/ml. Best results were shown by Lantana montevidensis against Pseudomonas aeruginosa [minimum inhibitory concentration (MIC) 8¦Ìg/ml] and Escherichia coli (MIC 32 ¦Ìg/ml), Zanthoxylum rhoifolium against E. coli (MIC, 256 ¦Ìg/ml) and Staphylococcus aureus (MIC 64 ¦Ìg/ml) and Croton zenhtneri against S. aureus (MIC 64 ¦Ìg/ml). Conclusion: Chemical tests indicated that a wide variety of natural product classes was present in those extracts that showed significant activities in the bioassays.
%K Araripe Basin
%K Artemia salina
%K ethanol extracts
%K larvicidal activities
%K pathogenic bacteria
%U http://www.phcog.com/article.asp?issn=0973-1296;year=2010;volume=6;issue=24;spage=331;epage=334;aulast=da