%0 Journal Article
%T IN VITRO IRREVERSIBLE BINDING AND DEGRADATION OF (R)- AND (S)-KETOPROFEN GLUCURONIDES TO PLASMA PROTEINS
%A PETER J. HAYBALL
%A KELLIE L. TUCK
%J Malaysian Journal of Pharmaceutical Sciences
%D 2007
%I 
%X This study describes the in vitro degradation studies of the diastereomeric ketoprofen glucuronides, under physiological conditions (pH 7.4, 37¡ãC, (R)-ketoprofen glucuronide t  = 30 min, (S)-ketoprofen glucuronide t  = 70 min) and the irreversible binding of diastereomeric ketoprofen glucuronides (15 ¦Ìg/ml) to human serum albumin (HSA) (289 ¦ÌM) and human plasma under physiological conditions (pH 7.4, 37oC). The (R)-ketoprofen glucuronide irreversibly bound to a greater extent in both human plasma and human serum albumin. This is the reverse to that found in previous studies. These findings further support the hypothesis that faster degradation of 1-O-acyl glucuronide (in this case the (R)-diastereomer) is associated with a greater extent of irreversible binding.
%K Ketoprofen
%K Ketoprofen glucuronide
%K Irreversible binding
%K Human serum albumin
%K Plasma
%U http://www.usm.my/mjps/MJPS%205%20(1)%202007/MJPS%205.1.5.pdf