%0 Journal Article
%T An explanatory randomised controlled trial of a nurse-led, consultation-based intervention to support patients with adherence to taking glucose lowering medication for type 2 diabetes
%A Andrew Farmer
%A Wendy Hardeman
%A Dyfrig Hughes
%A A. Toby Prevost
%A Youngsuk Kim
%A Anthea Craven
%A Jason Oke
%A Sue Boase
%A Mary Selwood
%A Ian Kellar
%A Jonathan Graffy
%A Simon Griffin
%A Stephen Sutton
%A Ann Louise Kinmonth
%J BMC Family Practice
%D 2012
%I BioMed Central
%R 10.1186/1471-2296-13-30
%X This was a parallel group randomised trial in adult patients with type 2 diabetes and HbA1c¡Ý7.5% (58 mmol/mol), prescribed at least one OGLM. Participants were allocated to a clinic nurse delivered, innovative consultation-based intervention to strengthen patient motivation to take OGLM regularly and support medicine taking through action-plans, or to usual care. The primary outcome was the percentage of days on which the prescribed dose of medication was taken, measured objectively over 12 weeks with an electronic medication-monitoring device (TrackCap, Aardex, Switzerland). The primary analysis was intention-to-treat.211 patients were randomised between July 1, 2006 and November 30, 2008 in 13 British general practices (primary care clinics). Primary outcome data were available for 194 participants (91.9%). Mean (sd) percentage of adherent days was 77.4% (26.3) in the intervention group and 69.0% (30.8) in standard care (mean difference between groups 8.4%, 95% confidence interval 0.2% to 16.7%, p£¿=£¿0.044). There was no significant adverse impact on functional status or treatment satisfaction.This well-specified, theory based intervention delivered in a single session of 30 min in primary care increased objectively measured medication adherence, with no adverse effect on treatment satisfaction. These findings justify a definitive trial of this approach to improving medication adherence over a longer period of time, with clinical and cost-effectiveness outcomes to inform clinical practice.Current Controlled Trials ISRCTN30522359
%K Adherence
%K Brief intervention
%K Diabetes
%U http://www.biomedcentral.com/1471-2296/13/30/abstract