%0 Journal Article
%T CXCL5 polymorphisms are associated with variable blood pressure in cardiovascular disease-free adults
%A Beitelshees Amber L
%A Aquilante Christina L
%A Allayee Hooman
%A Langaee Taimour Y
%J Human Genomics
%D 2012
%I BioMed Central
%R 10.1186/1479-7364-6-9
%X Objective Leukocyte count has been associated with blood pressure, hypertension, and hypertensive complications. We hypothesized that polymorphisms in the CXCL5 gene, which encodes the neutrophilic chemokine ENA-78, are associated with blood pressure in cardiovascular disease (CVD)-free adults and that these polymorphisms are functional. Methods and results A total of 192 community-dwelling participants without CVD or risk equivalents were enrolled. Two CXCL5 polymorphisms ( 156 G > C (rs352046) and 398 G > A (rs425535)) were tested for associations with blood pressure. Allele-specific mRNA expression in leukocytes was also measured to determine whether heterozygosity was associated with allelic expression imbalance. In  156 C variant carriers, systolic blood pressure (SBP) was 7 mmHg higher than in  156 G/G wild-type homozygotes (131 ¡À 17 vs. 124 ¡À 14 mmHg; P = 0.008). Similarly, diastolic blood pressure (DBP) was 4 mmHg higher in  156 C variant carriers (78 ¡À 11 vs. 74 ¡À 11 mmHg; P = 0.013). In multivariate analysis of SBP, age, sex, body mass index, and the  156 G > C polymorphism were identified as significant variables. Age, sex, and the  156 G > C SNP were further associated with DBP, along with white blood cells. Allelic expression imbalance and significantly higher circulating ENA-78 concentrations were noted for variant carriers. Conclusion CXCL5 gene polymorphisms are functional and associated with variable blood pressure in CVD-free individuals. The role of CXCL5 as a hypertension- and CVD-susceptibility gene should be further explored.
%K CXCL5
%K ENA-78
%K Blood pressure
%K Hypertension
%K Leukocytes
%U http://www.humgenomics.com/content/6/1/9