%0 Journal Article
%T Hormone replacement therapy is associated with gastro-oesophageal reflux disease: a retrospective cohort study
%A Helen Close
%A James M Mason
%A Douglas Wilson
%A A Pali S Hungin
%J BMC Gastroenterology
%D 2012
%I BioMed Central
%R 10.1186/1471-230x-12-56
%X 51,182 menopausal women were identified using the UK General Practice Research Database between 1995¨C2004. Of these, 8,831 were matched with and without hormone use. Odds ratios (ORs) were calculated for GORD and proton-pump inhibitor (PPI) use in hormone and non-hormone users, adjusting for age, co-morbidities, and co-pharmacy.In unadjusted analysis, all forms of hormone use (oestrogen-only, tibolone, combined HRT and progestogen) were statistically significantly associated with GORD. In adjusted models, this association remained statistically significant for oestrogen-only treatment (OR 1.49; 1.18¨C1.89). Unadjusted analysis showed a statistically significant association between PPI use and oestrogen-only and combined HRT treatment. When adjusted for covariates, oestrogen-only treatment was significant (OR 1.34; 95% CI 1.03¨C1.74). Findings from the adjusted model demonstrated the greater use of PPI by progestogen users (OR 1.50; 1.01¨C2.22).This first large cohort study of the association between GORD and HRT found a statistically significant association between oestrogen-only hormone and GORD and PPI use. This should be further investigated using prospective follow-up to validate the strength of association and describe its clinical significance.
%K Gastro-oesophageal reflux disease
%K Hormone replacement therapy
%K Menopause
%U http://www.biomedcentral.com/1471-230X/12/56/abstract