%0 Journal Article
%T Interval colon cancer in a Lynch syndrome patient under annual colonoscopic surveillance: a case for advanced imaging techniques?
%A Amy S Oxentenko
%A Thomas C Smyrk
%J BMC Gastroenterology
%D 2012
%I BioMed Central
%R 10.1186/1471-230x-12-50
%X We describe a 48-year-old woman with Lynch syndrome who was found to have an adenoma with invasive colorectal cancer within one year after a normal colonoscopy.Our patient illustrates two current concepts about Lynch syndrome: 1) adenomas are the cancer precursor and 2) such adenomas may be ¡°aggressive,¡± in the sense that the adenoma progresses more readily and more rapidly to carcinoma in this setting compared to usual colorectal adenomas. Our patient¡¯s resected tumor invaded only into submucosa and all lymph nodes were negative; in that sense, she represents a success for annual colonoscopic surveillance. Still, this case does raise the question of whether advanced imaging techniques are advisable for surveillance colonoscopy in these high-risk patients.
%K Lynch syndrome
%K Colorectal carcinoma
%K Surveillance
%U http://www.biomedcentral.com/1471-230X/12/50/abstract