%0 Journal Article
%T Efecto de Noni C sobre el da o hep¨¢tico inducido por tetracloruro de carbono en ratas Effect of Noni C on the carbon tetrachloride-induced hepatic damage in rats
%A Mar¨ªa del Carmen Jim¨¦nez Mart¨ªnez
%A Mar¨ªa Acelia Maceira Cubiles
%A Sara M Mart¨ªnez Mart¨ªn
%A Jos¨¦ Luis P¨¦rez de Alejo
%J Revista Cubana de Plantas Medicinales
%D 2013
%I ECIMED
%X Introducci¨®n: las enfermedades hep¨¢ticas son un serio problema de salud. El estudio de agentes de origen natural que disminuyan el da o hep¨¢tico inducido por sustancias qu¨ªmicas ha despertado un inter¨¦s especial. Objetivo: evaluar el efecto del Noni C sobre el da o hep¨¢tico inducido por tetracloruro de carbono, en modelo experimental desarrollado en ratas Wistar machos. M¨¦todos: se realiz¨® estudio experimental y se us¨® como control positivo el tetracloruro de carbono a dosis de 0,3 mL/kg de peso, intraperitoneal, durante 3 d¨ªas; y como control negativo soluci¨®n salina. Se utilizaron 4 dosis (85, 130, 170 y 215 mg/kg de peso) de Noni C durante 6 d¨ªas, postratamiento con tetracloruro de carbono. Se determinaron niveles de transaminasa glut¨¢mico pir¨²vica y glut¨¢mico oxalac¨¦tica; tambi¨¦n lesi¨®n hep¨¢tica como tumefacci¨®n celular, hepatitis reactiva, esteatosis y necrosis. Resultados: se obtuvo reducci¨®n significativa de las transaminasas glut¨¢mico pir¨²vica y glut¨¢mico oxalac¨¦tica a las dosis de 85 y 170 mg/kg de Noni C, y ausencia de necrosis y esteatosis en los grupos tratados con las dosis de 170 y 215 mg/kg de peso. Conclusiones: en los grupos tratados con Noni C disminuy¨® el da o hep¨¢tico inducido por el tetracloruro de carbono. Introduction: liver diseases are a serious health problem. The study of natural agents that can reduce the chemical substance-induced hepatic damage has aroused a particular interest. Objective: to evaluate the effect of Noni C on the carbon tetrachloride-induced hepatic damage in an experimental model developed in male Wistar rats. Methods: An experimental study was conducted in which the positive control was carbon tetrachloride at a dose of 0.3 mL/kg of weight, intraperitoneally administered for 3 days, and the negative control was saline solution. Four doses of Noni C(85, 130, 170 and 215 mg/kg of weight) were administered for 6 days, after treatment with the carbon tetrachloride. glutamic piruvic and glutamic oxaloacetic transaminase levels were determined, as well as hepatic lesions such as cell tumors, reactive hepatitis, steatosis and necrosis. Results: glutamic piruvic and glutamic oxaloacetic transaminases levels significantly decreased at doses of 85 and 170 mg/kg of Noni C, and no necrosis or steatosis was observed in the groups treated with 170 and 215 mg/kg doses. Conclusions: the carbon tetrachloride-induced hepatic damage diminished in the groups treated with Noni C.
%K noni
%K transaminasa glut¨¢mico pir¨²vica
%K transaminasa glut¨¢mico oxalac¨¦tica
%K rata
%K tetracloruro de carbono
%K da o hep¨¢tico
%K modelo experimental
%K Noni
%K glutamic piruvic transaminase
%K glutamic oxaloacetic transaminase
%K rat
%K carbon tetrachloride
%K hepatic damage
%K experimental model
%U http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962013000100011