%0 Journal Article
%T The synthesis and antitubercular activity of substituted hydrazone,2-pyrazoline-5-one and 2-isoxazoline-5-one derivatives possessing 1,3,4-thiadiazole moiety
%A Ba£żak Oral
%A Sevim Rollas
%J Marmara Pharmaceutical Journal
%D 2012
%I Marmara University Faculty of Pharmacy
%X Novel derivatives of substituted hydrazone (2a-e), 2-pyrazoline-5-one (3a-e, 4ae) and 2-isoxazoline-5-one (5a-e) derivatives possessing 1,3,4-thiadiazole moiety were synthesized and evaluated for their antitubercular activity. The highest inhibitions were observed with the synthesized compounds are 87% for 3-methyl-4-[4-(5-cyclohexylamino- 1,3,4-thiadiazole-2-yl)phenylhydrazono]-2-isoxazoline-5-one (5b) and 86% for ethyl 2-[4-(5-cyclohexylamino-1,3,4-thiadiazole-2-yl)phenylhydrazono]-3-oxobutirate (2b). Compounds 2b and 5b could be a good initial point to develop new lead compound.
%K : 1
%K 3
%K 4-thiadiazole
%K 2-pyrazolin-5-one
%K 2-isoxazoline-5-one
%K hydrazone
%K antitubercular activity
%U http://www.marmaraeczacilikdergisi.com/text.php3?id=304