%0 Journal Article
%T Synthesis and characterization of triazenes derived from sulfonamides
%A Seda ¨¹nsalan
%A Pelin £¿£¿kla
%A £¿. G¨¹niz K¨¹£¿¨¹kg¨¹zel
%A Sevim Rollas
%J Marmara Pharmaceutical Journal
%D 2011
%I Marmara University Faculty of Pharmacy
%X ABSTRACT: A series of novel triazene derivatives 1-3, 1a-3a were synthesized by the coupling of diazonium salts of amines (sulfaguanidine, sulfapyridine, sulfamethoxazole) with N-methylaniline / p-nitroaniline in acidic media. The structures of the synthesized compounds were confirmed by the spectral data (UV, IR,1H-NMR, APCI-MS) and elemental analysis. The effects of all the compounds on A 549 and L 929 cell lines growth were investigat-ed. The cytotoxic and antitumor activities of these compounds have not been in vitro aganist A 549 and L 929 cell lines
%K Triazene
%K sulfonamide
%K prontosil
%K azo reduction
%U http://www.marmarapharmaceuticaljournal.com/pdf/pdf_MPJ_258.pdf