%0 Journal Article
%T Synthesis and voltammetric detection of 1H-benzimidazole derivatives on the interaction with DNA
%A Ay£¿e Selcen Alpan
%A £¿vg¨¹ Y£¿lmaz
%A Ozan K£¿l£¿£¿kaya
%A P£¿nar Kara
%J Marmara Pharmaceutical Journal
%D 2012
%I Marmara University Faculty of Pharmacy
%X In this study, synthesis and determination of interaction between DNA and 1Hbenzimidazole derivatives has been performed by using electrochemical genosensor technology. Detection of DNA ¨C drug interaction mechanism relies on monitoring Differential pulse voltammetric (DPV) responses of drugs at disposable graphite electrodes (DGEs). Interaction of 7 different benzimidazole derivates between double-stranded (ds) and singlestranded (ss) DNA were observed by changing the voltammetric signals of drugs at the detection limits of 0.62 nM of compound 1, 1.23 nM of 2, 1.26 nM of 3, 1.08 nM of 4, 1.13 nM of 5, 0.69 nM of 6 and 0.42 nM of 7, respectively.
%K 1H-benzimidazole
%K electrochemical genosensor
%K DNA-drug interaction
%K synthesis
%U http://www.marmaraeczacilikdergisi.com/text.php3?id=284