%0 Journal Article
%T Evaluation of HIV-Leishmania co-infection in patients from the northwestern Paran¨¢ State, Brazil = Avalia  o da co-infec  o HIV-Leishmania em pacientes da regi o noroeste do Estado do Paran¨¢, Brasil
%A ¨¦lide Aparecida Oliveira
%A Fernanda Almeida Celid£¿nio
%A Tha¨ªs Gomes Verzignassi Silveira
%A Maria Valdrinez Campana Lonardoni
%J Acta Scientiarum : Health Sciences
%D 2011
%I Eduem - Editora da Universidade Estadual de Maring¨¢
%X Leishmaniasis occurs throughout the world and is one of the opportunistic infections that attack HIV-infected individuals. Few data are available on American cutaneous leishmaniasis (ACL) in HIV-infected patients. Current research investigates the occurrence ofHIV-Leishmania co-infection in HIV-infected individuals in an endemic region in Southern of Brazil. A non-randomized transversal investigation, molecular and serum epidemiologic type, on the occurrence of ACL in 169 HIV-infected patients was undertaken. The patients were followed up at the Integrated Nucleus of Health of the city Maring¨¢, Southern of Brazil. Results showed that 13 (7.7%) of the HIV-infected patients also presented Leishmania (Viannia) DNA, detectable in blood by PCR. Serology, direct research, culture and PCR in skin material produced negative results. PCR positiveness for Leishmania was not associated with CD4 T lymphocytes count, opportunistic disease, treatment, use of proteases inhibitors, tattooing/piercing or use of injectable drugs, residential environment or previous ACL history. Results show that HIVinfected patients who live in endemic areas may reveal Leishmania DNA in the blood without any ACL symptoms. Above findings may be attributed to anti-retrovirus medicine that controls viral replication and maintains the functionality of the immune system and to a possible anti- Leishmania activity of these drugs. As leishmanioses ocorrem em todo o mundo e s o infec  es oportunistas que afetam indiv¨ªduos portadores do v¨ªrus HIV. Este estudo investigou a ocorr¨ºncia da co-infec  o HIV-Leishmania em portadores do HIV numa regi o end¨ºmica para LTA do Sul do Brasil. Foi realizado estudo transversal, n o randomizado, utilizando metodologia molecular e sorol¨®gica, sobre a ocorr¨ºncia de LTA em 169 portadores do HIV. Foram estudados pacientes atendidos no N¨²cleo Integrado de Sa¨²de de Maring¨¢, Paran¨¢, Sul do Brasil. Observou-se que 13 (7,7%) dos pacientes infectados pelo HIV tamb¨¦m apresentavam o DNA de Leishmania (Viannia), detect¨¢vel no sangue por PCR. A sorologia, pesquisa direta de Leishmania, cultura e PCR de les es de pele foram negativas. A positividade da PCR n o estava associada ¨¤ contagem de linf¨®citos T CD4+, doen a oportunista, tratamento, uso de inibidores de protease, tatuagem, uso de drogas injet¨¢veis, ambiente da resid¨ºncia ou hist¨®ria pr¨¦via de LTA. Os resultados mostraram que indiv¨ªduos portadores do v¨ªrus HIV que residem em ¨¢rea end¨ºmica podem apresentar o DNA de Leishmania sem manifestar sintomas de LTA. Estes resultados podem ser atribu¨ªdos a a  o dos medicamentos an
%K american cutaneous leishmaniasis
%K HIV
%K co-infection
%K polymerase chain reaction
%K leishmaniose tegumentar americana
%K HIV
%K co-infec  o
%K rea  o em cadeia da polimerase
%U http://periodicos.uem.br/ojs/index.php/ActaSciHealthSci/article/view/6976/6979