%0 Journal Article
%T Genome-wide linkage analysis of QTL for growth and body composition employing the PorcineSNP60 BeadChip
%A Ana Isabel Fern¨¢ndez
%A Dafne P¨¦rez-Montarelo
%A Carmen Barrag¨¢n
%A Yuliaxis Ramayo-Caldas
%A Noelia Iba£¿ez-Escriche
%A Anna Castell¨®
%A Jose Luis Noguera
%A Luis Sili¨®
%A Josep Mar¨ªa Folch
%A M Carmen Rodr¨ªguez
%J BMC Genetics
%D 2012
%I BioMed Central
%R 10.1186/1471-2156-13-41
%X Three generations (F3, Backcross 1 and Backcross 2) of the IBMAP and their related animals were genotyped with PorcineSNP60 BeadChip. A total of 8,417 SNPs equidistantly distributed across autosomes were selected after filtering by quality, position and frequency to perform the QTL scan. The joint and separate analyses of the different IBMAP generations allowed confirming QTL regions previously identified in chromosomes 4 and 6 as well as new ones mainly for backfat thickness in chromosomes 4, 5, 11, 14 and 17 and shoulder weight in chromosomes 1, 2, 9 and 13; and many other to the chromosome-wide signification level. In addition, most of the detected QTLs displayed narrow confidence intervals, making easier the selection of positional candidate genes.The use of higher density of markers has allowed to confirm results obtained in previous QTL scans carried out with microsatellites. Moreover several new QTL regions have been now identified in regions probably not covered by markers in previous scans, most of these QTLs displayed narrow confidence intervals. Finally, prominent putative biological and positional candidate genes underlying those QTL effects are listed based on recent porcine genome annotation.
%K QTL
%K PorcineSNP60 Beadchip
%K Growth
%K Fatness
%K Body conformation
%U http://www.biomedcentral.com/1471-2156/13/41/abstract