%0 Journal Article
%T Toxicity Of The Essential Oil Of The Cytral Chemotype Of Lippia Alba (Mill.) N. E. Brown Toxicidad del aceite esencial de Lippia alba (Mill.) N. E. Brown quimiotipo citral
%A Jes迆s Olivero-Verbel
%A Ang谷lica Guerrero-Castilla
%A Elena Stashenko
%J Acta Toxicol車gica Argentina
%D 2010
%I 
%X The essential oil (EO) of Lippia alba (Mill.) N. E. Brown (Verbenaceae) has been traditionally used to treat several diseases. In this study, the acute toxic effects of the citral chemotype of L. alba EO were evaluated in mice. Animals were treated via intraperitoneal receiving the L. alba essential oil at doses between 50 and 2500 mg/kg, and the control group received sesame oil (vehicle). The EO induced dose-dependent neurotoxic effects at doses greater than 1000 mg/kg, including decreased locomotion, motor skills and muscle strength, hypotonia, dyspnea, kyphosis and convulsions. The EO was lethal at a dose of 2500 mg/kg. Animals receiving 1000 mg/kg were euthanized at the end of the treatment period and their blood and livers were collected for analysis. Mice exposed to L. alba EO presented signifcantly greater plasma alanine aminotransferase (ALT) activities than the control group. Liver histological changes included mild infammation, in particular, an increase in nuclear size. Compared to vehicle control group, changes in expression for selected genes were signifcant for FABP5, a fatty acid transport related gene. In summary, the intraperitoneal administration of L. alba EO (citral chemotype) causes neurological damage in mice at doses equal or greater than 1500 mg/kg, whereas at 1000 mg/kg, it generates mild liver damage. Therefore, the systemic use of this EO raises concerns about its safety. El aceite esencial (AE) de Lippia alba (Mill.) NE Brown (Verbenaceae) ha sido utilizado tradicionalmente para tratar varias enfermedades. En este estudio, los efectos t車xicos agudos del AE de Lippia alba quimiotipo citral fueron evaluados en ratones. Los animales fueron tratados por v赤a intraperitoneal recibiendo el AE en dosis entre 50 y 2500 mg/kg de peso, y el grupo control aceite de s谷samo (veh赤culo). Dosis superiores a 1000 mg/kg del AE mostraron efectos neurot車xicos incluyendo disminuci車n de la locomoci車n e hipoton赤a, disnea, cifosis y convulsiones. El AE fue letal a la dosis de 2500 mg/kg. Veinticuatro horas despu谷s de que los animales fueron tratados con 1000 mg/kg del AE se les realiz車 eutanasia y su sangre e h赤gado fueron recolectados para an芍lisis. Los ratones expuestos al AE de L. alba, presentaron actividad alanina aminotransferasa (ALT) en plasma signifcativamente mayor que el grupo control. Dentro de los cambios histol車gicos hep芍ticos se incluyen infamaci車n leve, en particular, un aumento del tama o nuclear. En comparaci車n con el grupo control, la expresi車n de genes seleccionados tuvo diferencias signifcativas para FABP5, un gen relacionado co
%K Aceite esencial
%K Lippia alba
%K Da o neurol車gico
%K Toxicidad aguda
%K Essential oil
%K Lippia alba
%K Neurological damage
%K Acute toxicity
%U http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-37432010000100003