%0 Journal Article
%T High Performance Liquid Chromatographic Analysis of Almotriptan Malate in Bulk and Tablets
%A Petikam lavudu
%A Avula Prameela Rani
%A Chepuri Divya
%A Chandra Bala Sekaran
%J Advanced Pharmaceutical Bulletin
%D 2013
%I Tabriz University of Medical Sciences
%R 10.5681/apb.2013.030
%X Purpose: A simple RP-HPLC method has been developed and validated for the determination of almotriptan malate (ATM) in bulk and tablets. Methods: Chromatographic separation of ATM was achieved by using a Thermo Scientific C18 column. A Mobile phase containing a mixture of methanol, water and acetic acid (4:8:0.1 v/v) was pumped at the flow rate of 1 mL/min. Detection was performed at 227 nm. According to ICH guidelines, the method was validated. Results: The calibration curve was linear in the concentration range 5¨C60 ¦Ìg/mL for the ATM with regression coefficient 0.9999. The method was precise with RSD <1.2%. Excellent recoveries of 99.60 - 100.80% proved the accuracy of the method. The limits of detection and quantification were found to be 0.025 and 0.075 ¦Ìg/mL, respectively. Conclusion: The method was successfully applied for the quantification of ATM in tablets with acceptable accuracy and precision.
%K Almotriptan Malate
%K HPLC
%K Validation
%K Tablets
%K Analysis
%U http://journals.tbzmed.ac.ir/PDF/APB/Manuscript/APB-3-183.pdf