%0 Journal Article
%T CMV and Immunosenescence: from basics to clinics
%A Solana Rafael
%A Tarazona Raquel
%A Aiello Allison E
%A Akbar Arne N
%J Immunity & Ageing
%D 2012
%I BioMed Central
%R 10.1186/1742-4933-9-23
%X Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates ˇ°immunosenescenceˇ±. This contention remains controversial and was the primary subject of the Third International Workshop on CMV & Immunosenescence which was held in Cordoba, Spain, 15-16th March, 2012. Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization of CMV-specific T cells, impact of CMV infection and ageing on innate immunity, and finally, most important, the clinical implications of immunosenescence and CMV infection. Here we summarize the major findings of this workshop.
%U http://www.immunityageing.com/content/9/1/23