%0 Journal Article
%T Significant pain relief with loading dose zoledronic acid in bone metastases is only seen in patients with elevated initial serum C telopeptide (CTX)
%A Dekoninck J
%A Geurs F
%A De Loecker R
%A Deprest Y
%J Pragmatic and Observational Research
%D 2011
%I Dove Medical Press
%X J Dekoninck1, F Geurs1, R De Loecker2, Y Deprest21Department of Medical Oncology, 2Laboratory, Regional Hospital Sint Maria, Halle, BelgiumAbstract: In symptomatic bone metastases with significant pain, refractory to standard analgesics and radiotherapy, loading dose zoledronic acid (ZA) represents a simple and nontoxic treatment to obtain significant pain relief in a very short time. Its analgesic effect is limited to patients with massive osteoclast activation with high initial serum C-telopeptide (CTX). The pain reduction is proportionally correlated with the reduction of CTX.Keywords: bone resorption, bisphosphonates, CTX levels, VAS score
%U http://www.dovepress.com/significant-pain-relief-with-loading-dose-zoledronic-acid-in-bone-meta-a7975