%0 Journal Article
%T Role of gamma-delta T cells in host response against Staphylococcus aureus-induced pneumonia
%A Ping Cheng
%A Tao Liu
%A Wei-Ying Zhou
%A Yuan Zhuang
%A Liu-sheng Peng
%A Jin-yu Zhang
%A Xu-hu Mao
%A Gang Guo
%A Yun Shi
%A Quan-ming Zou
%J BMC Immunology
%D 2012
%I BioMed Central
%R 10.1186/1471-2172-13-38
%X Mice infected with S. aureus intranasally showed rapid 污汛 T cells accumulation in the lung. Deficiency of 污汛 T cells led to attenuated bacterial clearance and less tissue damage in lung compared with WT mice. Moreover, TCR-汛ˋ/ˋ mice exhibited impaired neutrophil recruitment and reduced cytokine production at the site of infection. The 污汛 T cells in response to pulmonary S. aureus infection mainly secreted IL-17 and 污汛 T cells deficiency reduced IL-17 production, which might regulate the production of neutrophil-inducing cytokine/chemokine in the S. aureus-infected lungs.Accumulation of 污汛 T cells in the lungs to S. aureus infection is beneficial for bacteria clearance and also contributes to the tissue damage. These cells were the primary source of IL-17, which might influence the recruitment of neutrophils at the early stage of infection.
%U http://www.biomedcentral.com/1471-2172/13/38/abstract