%0 Journal Article
%T Theoretical elements of veterinary therapeutics
%A Cristina
%A T. Romeo.
%A Schmerold
%A I.
%A Tuns
%A I. C.
%J Medicamentul Veterinar
%D 2010
%I Romanian National Association of the Veterinary Products Manufacturers
%X The present essay describes, logically and in a synthetic way, the main elements of veterinary therapeutics. The first part refers to the concept of dose and the main factors affecting its establishment, presenting the elements related to: weight and body surface area, the therapeutic range, animal¡¯s size, genetic factors, specific variations, digestive tract¡¯s anatomy, factors related to age, sex, pregnancy, time of administration, tolerance and intolerance to medications, and factors that may influence response to the medication (diminished/amplified response, dose administrations¡¯ toxicity, etc.). Following are revealed the key factors that determine the administration¡¯s, frequency like: drug¡¯s cleareance,drug¡¯s concentration, administration rate, repeated-dose effect and the frequency establishing, etc. There are no missing also the elements that are describing: the plateau effect, zero-order kinetics, drug residues effect, the dose-effect relationship, the first-pass effect, latency and intensity, the risk-benefit ratio in the veterinary therapy, to full understanding of the concepts by the vet practicians.
%K veterinary therapeutic
%K theoretical elements
%U http://www.veterinarypharmacon.com/docs/604-2010-%20ART.2.pdf