%0 Journal Article
%T Development and validation of a RP-HPLC method for the quantization studies of ivermectin in solutions dosage forms
%A Elena Gabriela Oltean
%A Nica A.
%J Medicamentul Veterinar
%D 2011
%I Romanian National Association of the Veterinary Products Manufacturers
%X An isocratic high¨Cperformance liquid chromatography (HPLC) procedure was developed for quantitative determination of ivermectin in solutions dosage forms. HPLC separation was carried out by reversed phase chromatography KROMASIL C18 (150 mm x 4.6 mm i.e.; 5 ¦Ìm particle size), held at 25¡ãC. The mobile phase consisted of methanol/ water (90/ 10 v/ v), run at flow rate of 1 mL/min and with UV detection at 254 nm. Method validation investigated parameters such as linearity (r2 = 0.9999), range, precision, accuracy, specificity, limit of detection and limit of quantification. The described method can be successfully applied for the analysis of solutions dosage forms.
%K ivermectin
%K Romivermectin
%K reversed phase high performance liquid chromatography RP¨CHPLC
%U http://www.veterinarypharmacon.com/docs/995-2011-ART.%208.%20eng.pdf